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Silver doped TiOsub2/sub nanoparticles (Ag/TiOsub2/sub) were synthesized by the photochemicalreduction of silver nitrate with oxalic acid and ultraviolet (UV) radiation in the presence of TiOsub2/sub (Degussa P-25). Inactivation of Bacteriophage MS-2 by the Ag/TiOsub2/sub nanoparticles, the parent TiOsub2/sub material,and silver nanoparticles (nAg) were assessed in small batch systems subjected to UV-Aradiation. The viral suspensions were assayed via the double agar layer method. The resultsobtained with silver doped TiOsub2/sub were compared with those obtained with TiOsub2/sub alone, nAg alone,and UV-A alone to determine if the presence of Ag enhances viral inactivation by TiOsub2/sub and if asynergism exists between the antiviral activity of nAg and that of TiOsub2/sub. Chick's law was used tomodel the inactivation kinetics. Ag/TiOsub2/sub initially inactivated MS-2 faster than bare TiOsub2/sub, with arate constant of 0.17 ssup-1/sup vs. 0.12 ssup-1/sup, respectively. However, a tailing effect was observed withthe Ag/TiOsub2/sub, and the inactivation rate slowed after 20 s of irradiation, corresponding toapproximately 3.5 LOG removal. nAg alone and UV-A alone were not found to significantlyinactivate MS-2, supporting the hypothesis that a synergism occurs between nAg and TiOsub2/sub whencombined. The understanding of the inactivation mechanisms will be used for the developmentof highly efficient Ag/TiOsub2/sub materials for virus inactivation. Includes 22 references, figures.

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Edition: Vol. - No. Published: 11/01/2008 Number of Pages: 11File Size: 1 file , 790 KB