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Recent work has shown that polychromatic ultraviolet (UV) sources, such as medium-pressure(MP) UV, are significantly more effective than low-pressure (LP) UV at inactivatingadenovirus in cell culture infectivity assays (Eischeid et al., 2009; Linden et al.,2007). It is thought that LP UV primarily damages the viral DNA, and that thisdamage may be repaired during cell culture infectivity assays, allowing the virusto successfully infect cells and escape inactivation. Such host cell reactivation ofthe damaged virus does not appear to occur after MP UV irradiation, and thismay be because of more widespread, extragenomic damage to the viral particlecaused by medium pressure UV. Includes 10 references, figures.

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Edition: Vol. - No. Published: 11/01/2009 Number of Pages: 7File Size: 1 file , 750 KB